Distribution of Ras pathway mutations in children with JMML. Data were reported by (A) the EWOG-MDS (N = 142)⁸⁶  or (B) the Japanese JMML Cooperative Study Group (N = 132).⁷⁴  The 3 cases of the Japanese cohort with ALK or ROS1 rearrangement had been excluded from the analysis. Cases with monosomy 7 are indicated by the hatched slices. The analyses do not include patients with NS/MPD.