Comparison of a hematopoietic tree diagram with a single-cell transcriptomic landscape. (A) Schematic showing one of the classic views of the hematopoietic cell hierarchy. Dashed boxes show 3 compartments encompassing cells of different potency: multipotent cells on top, bipotent/oligopotent cells in the middle, and terminally differentiated (unipotent) cells at the bottom. (B) A dimensionality reduction projection (UMAP algorithm) of single-cell transcriptomes from the bone marrow mononuclear cell fraction. Arrows indicate main directions of differentiation, inferred from analysis of typical marker genes. Gray indicates unassigned cells, in which identity based on markers is unclear (data set downloaded from Human Cell Atlas data portal and processed by I.K.). CMP, common myeloid progenitor; CLP, common lymphoid progenitor; GMP, granulocyte-monocyte progenitor; HSPC, hematopoietic stem and progenitor cell; LMPP, lymphoid-primed MPP; MEP, megakaryocyte-erythroid progenitor; Mk, megakaryocyte.