Factors influencing hematopoietic clonal expansion. A model of various stochastic and deterministic factors that may affect the likelihood of clonal expansion of a cell that has acquired a driver mutation. Combinations of risks at a given time point would additively affect the total risk. The impact of each factor, and thus the shape and angle of the depicted lines, would vary depending on the specific driver mutation. Pie charts show potential differences in the contribution of the various factors to clonal expansion in the context of different driver mutations.^29,61,62,82