Figure 4.
MAA868 prolongs aPTT in cynomolgus monkeys and inversely lowers FXIf when dosed SC. MAA868 was administered subcutaneously to 2 female cynomolgus monkeys at 3, 10, and 30 mg/kg on days 1, 85, and 114, respectively. Two control animals received vehicle on days 1, 85, and 114. MAA868 plasma exposure, FXIf, and aPTT as a function of time are shown for the 2 individual animals (A) and (B) starting at 6 h postdose. Doubling of aPTT (2× baseline aPTT) and free FXI lower level of detection (LLD) are indicated by dashed lines. Total plasma MAA868 and FXIf were quantified by using custom sandwich immunoassays.