Manhattan plot of the gene-based recessive diplotype association results. The association P-value testing hemochromatosis association for each gene (−log₁₀p plotted on the ordinate) on different chromosomes is shown in alternating navy blue and yellow along the abscissa, with the experiment-wise significance level for the gene-based analyses across the exome (experiment-wise α = 3.14 × 10⁻⁶) depicted in red.