Ab initio envelopes and molecular models of ADAMTS13 C-terminal truncations. Envelopes calculated from SAXS data are rendered as gray surfaces. ADAMTS13 domains are colored similarly to Figure 1A: M (orange), D (yellow), T1 (green), C (sky blue), S (lavender), T3 and T6 (yellow), T2, T4, T5, T7, and T8 (green), T4-T5 linker (gray), T8-CUB1 linker (gray), CUB1 (red), CUB2 (brick red). All constructs have the active site mutation E225Q.