Proposed allosteric activation of full-length human ADAMTS13, delT3-6, and pADAMTS13. Human ADAMTS13 (A) and pADAMTS13/delT3-6 (B). MDTCS (orange = M domain; yellow = D domain; green = T1 domain; sky blue = C domain; lavender = S domain), T2, T4, and T8, dark green; T3, T5, and T7, green; linker between T4 and T5 and between T8 and CUBs, gray; CUB1, red; and CUB2, brick red. VWF: A2 and A3, pink; D4, light blue; and C1, lavender.