Serum biomarkers associated with PFS in patients with aggressive NHL. (A) The association of pre-lymphodepletion (pre-LD) serum LDH level with the hazard of a PFS event, adjusting for day 0 MCP-1 and peak IL-7 concentrations. The vertical dashed line shows the upper limit of normal LDH. (B) The association of serum day 0 MCP-1 with the hazard of a PFS event, adjusting for pre-LD LDH level and peak IL-7 concentration. (C) The association of serum peak IL-7 concentration with the hazard of a PFS event, adjusting for pre-LD LDH level and day 0 MCP-1 concentration. (D) Estimated combined effect of pre-LD LDH level and day 0 MCP-1 concentration on hazard of a PFS event. (E) Estimated combined effect of pre-LD LDH level and peak IL-7 concentration on hazard of a PFS event. The HRs are shown in the colored bars to the right of each figure in panels D-E. Serum biomarkers were modeled as restricted cubic splines with 3 knots.