WES reveals PD-L1–altered DLBCLs are enriched for mutations in immune-related genes. (A) Profiles of recurrent nonsynonymous somatic mutations in DLBCLs with and without PD-L1 alterations. Each column represents a separate DLBCL case. Above each column is the mutational burden of each case as assessed by the total number of nonsynonymous somatic mutations. (B) Nonsynonymous somatic mutations (NSSMs) in genes involved in antigen presentation and T-cell costimulation in DLBCLs with vs without PD-L1 gene alterations (P = .02, Mann-Whitney U test). (C) Total mutational burden in DLBCLs with and without PD-L1 alterations (P = .34, Wilcoxon rank sum test with continuity correction).