Repertoire of recurrent deleterious mutations observed in 841 patients with CLL. (A) The percentage of cases with mutations in each gene is represented by red bars. (B) Heat map of IGHV mutational status, ZAP-70 expression, cytogenetic aberrations, and deleterious mutations observed in this cohort. Purple boxes indicate which patients have CLL cells with IGHV_UM, brown boxes indicate which patients have CLL cells expressing ZAP-70, blue boxes indicate which patients have CLL cells carrying cytogenetic deletions (Del13q, Trisomy 12, Del11q, or Del17p), and gray boxes indicate missing data. Yellow boxes represent missense mutations, black frameshift mutations, green splicing mutations, and red nonsense mutations.