Combination of chemotherapeutic agents and GPVI blockade decreases tumor growth. TrampC1 and AT-3 tumor-bearing mice were treated with Doxil and 3H-PTX in combination with IgG control, R300, or JAQ1 F(ab′)2. After 2 and 24 hours, the concentration of Doxil (A, 2 hours) or 3H-PTX (B, 2 hours and 24 hours) within the tumor was measured. Mean with SD is displayed. ***P < .001, **P < .01, and *P < .05; Kruskal-Wallis with Dunn’s multiple comparisons test. Tumor volume was measured in TrampC1 (C) and AT-3 (D) tumor-bearing mice every second day. Data are presented as mean ± SEM. ***/###P < .001, **/##P < .01, and */#P < .05 (where * stands for the group treated with the chemotherapeutic agent and # the vehicle in the respective color); Kruskal-Wallis with Dunn’s multiple comparisons test. ID/g, injected dose per gram.