Impaired hematopoiesis, motor abnormalities, and cognitive deficits in Efl1^K983R/K983Rmice. (A) Bone marrow cellularity in wild-type and homozygous Efl1^K983R/K983R mice is indicated. (B-C) Frequencies of hematopoietic stem cells (HSCs); megakaryocyte, granulocyte, erythroid progenitors (pMegE); megakaryocyte progenitors (MkP); myeloid progenitors (pre–granulocyte-monocyte/granulocyte-monocyte progenitors); and erythroid progenitors (pCFU-E and CFU-E) in the bone marrow in the indicated genotypes are shown (n = 8 per genotype).³⁴  EFL1 K983R mutation affects hematopoiesis. Hemoglobin levels (D), platelets (E), and total white blood cell counts (F). (G) Gait abnormalities in K983R mutant mice. Gait was analyzed using a qualitative scoring system at selected time points. Scores are explained in Materials and methods. (H) Motor deficits in EFL1 K983R mutant mice. Free wheel-running activity (over 7 nights, 3 months of age) for the indicated genotypes. (I) Cognitive deficits in K983R mutant mice. Y maze habituation testing of the indicated genotypes at 3 months of age. For all tests, P values are indicated.