Changes in viral epitope recognition at 1 year post-HCT. HCT pairs were assigned to a D/R status individually for each virus (each HCT pair could contribute to a different category for each virus) based on the described thresholding algorithm. Linear mixed modeling then evaluated group mean gain or loss of epitopes with respect to the pre-HCT sample of the donor (A-D) or recipient (E-H). Viruses for which there was net loss are shown with the estimate and 95% CI in blue (P < .05), and those with net gain are shown in red (P < .05); if the 95% CI crossed 0, black is used. Overall, D⁻/R⁻ pairs showed no changes from either D or R baseline (A,E). With respect to D, the D⁺/R⁻ pairs mainly lost epitope recognition across multiple viruses (B) and the D⁻/R⁺ pairs gained epitopes across many viruses after HCT (C). With respect to either D or R baseline, D⁺/R⁺ pairs mainly showed loss of epitopes (D,H). HHVs are shown here alphabetically by number, wherein HHV-1/2 = HSV 1/2; HHV-3 = varicella zoster virus; HHV-4 = Epstein-Barr virus; HHV-5 = cytomegalovirus; HHV6A/B, 7 = roseolaviruses.