Genetic alterations of the IKZF1 gene at chromosome band 7p12.2 in pediatric ALL. Red boxes indicate the observed approximate frequencies of the different types of genetic aberrations: deletions (bottom left), gene fusions (bottom right), and somatic as well as germline single-nucleotide variants (top). The 2 intronic germline risk variants identified in genome-wide association studies are indicated by their Reference SNP cluster ID. Frequencies (percentages) of the most common specific deletions (DEL) within the group of IKZF1-deleted ALL are indicated in black. Chr, chromosome; UTR, untranslated region.