Figure 1.
NAC extends the lifespan in a JAK2V617Fknockin mouse model of MPN. (A) Kaplan-Meyer survival curve representing JAK2V617F mice whose drinking water contained NAC (2 g/L) or aspirin (16 mg/L), **P < .01 log-rank test. Spleen (B) and liver (C) weights at euthanasia or death. (D-F) Peripheral blood counts, including white blood cell count (D), hematocrit (E), and platelet count (F), in WT or JAK2V617F mice treated with plain water or NAC-containing water. Error bars represent standard error of the mean (SEM); n = 6-12 per group. Shown are representative data from 2 biological replicates. ns, not significant.

NAC extends the lifespan in a JAK2V617Fknockin mouse model of MPN. (A) Kaplan-Meyer survival curve representing JAK2V617F mice whose drinking water contained NAC (2 g/L) or aspirin (16 mg/L), **P < .01 log-rank test. Spleen (B) and liver (C) weights at euthanasia or death. (D-F) Peripheral blood counts, including white blood cell count (D), hematocrit (E), and platelet count (F), in WT or JAK2V617F mice treated with plain water or NAC-containing water. Error bars represent standard error of the mean (SEM); n = 6-12 per group. Shown are representative data from 2 biological replicates. ns, not significant.

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