Fig. 2.
Fig. 2. Morphology of red cells from C57BL, NY1KO γH, NY1KO γM, and BERK mice. / (A), C57BL; (B), NY1KO γH; (C), NY1KO γM; and (D), BERK mice. Note that the NY1KO γH mouse red cells are hyperchromic when compared with C57BL, and the BERK mouse red cells are hypochromic (open arrows). Solid arrows indicate circulating irreversibly sickled cells (ISCs) that can be found in all 3 types of transgenic mice. The red cells of the NY1KO γH mouse are normochromic or hyperchromic when compared with the control C57BL mouse and, in contrast, the red cells of the BERK mouse are severely hypochromic when compared with the C57BL mouse. These results are in agreement with the Percoll-Larex continuous density gradients (Figure 1), which show that the BERK mice have a much lower MCHC than either NY1KO γM or γH mice. This is particularly apparent when the BERK mice are compared with the NY1KO γM mice that have approximately the same average reticulocyte counts.

Morphology of red cells from C57BL, NY1KO γH, NY1KO γM, and BERK mice.

(A), C57BL; (B), NY1KO γH; (C), NY1KO γM; and (D), BERK mice. Note that the NY1KO γH mouse red cells are hyperchromic when compared with C57BL, and the BERK mouse red cells are hypochromic (open arrows). Solid arrows indicate circulating irreversibly sickled cells (ISCs) that can be found in all 3 types of transgenic mice. The red cells of the NY1KO γH mouse are normochromic or hyperchromic when compared with the control C57BL mouse and, in contrast, the red cells of the BERK mouse are severely hypochromic when compared with the C57BL mouse. These results are in agreement with the Percoll-Larex continuous density gradients (Figure 1), which show that the BERK mice have a much lower MCHC than either NY1KO γM or γH mice. This is particularly apparent when the BERK mice are compared with the NY1KO γM mice that have approximately the same average reticulocyte counts.

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