Syk and Src-like tyrosine kinases are, respectively, involved in the MCP-1–induced JNK1 and p38 activations.

MonoMac6 cells, untreated or preincubated 2 hours with 10 μM PP2 or 5 μg/mL piceatannol, were exposed following different time courses to 20 nM MCP-1. The activity and the amount of each MAPK were evaluated as previously described in Figure 1 and in “Materials and methods.” The results are representative of 2 experiments.