Serum clearance of anti-CD40 ligand mAb.

Hamster anti-CD40 ligand mAb levels were determined by ELISA of serum at 3 to 38 weeks after last antibody injection (1.6 mg/injection). Serum levels from the groups presented in Figure 6 are shown. There were 5 mice per group through week 15; at week 38 there were 5 mice in the 40 million group, 2 mice in the 80 million group, and 3 mice in the 120 million group. Background values of 0 to 1.42 ng/mL were found in normal BALB/c mouse serum. Zero indicates no detectable antibody at 38 weeks.