Recruitment of neutrophils into cytokine-transfected tumor and their involvement in its destruction.

Local release of the cytokine from transfected tumor cells acts on the host endothelium and reactive leukocytes, mainly tumor-associated macrophages. The cytokine and chemokine cascade and endothelial adhesion molecule expression thus induced results in PMN recruitment and activation. Tumor destruction on the part of activated PMNs is achieved through their release of a variety of factors (cytokines, enzymes, chlorinated oxidants, etc) whose effects include direct tumor killing, extracellular lysis, inhibition of angiogenesis and activation of other reactive cells, resulting in NK cell, T cell, and antibody-dependent cytotoxicity.