Localization of the minimal region of deletion and patients' breakpoints on the 40-Mb 11q contig.

The locations of the trinucleotide repeats and the FRA11Bfragile site are indicated by bold type. The various genes and D11S markers in the region are also indicated at the top of the figure, from centromeric to telomeric and from left to right. Below this the location of various YACs and PACs and their relative sizes are indicated by gray boxes together with the relevant identification number, corresponding to the identification number in the text. Patient identification numbers are indicated on the left of black horizontal boxes that correspond to the portion of chromosome 11 present in the patient CLL material, as determined by FISH and haplotype analysis. (+) The nearest retained marker to the deleted region. The unfilled area between the boxes represents the area of deletion. Grey boxes represent the maximum extent of the region in which the breakpoint must be located with the most proximal deleted marker, denoted by (−). Proximally our minimal region of deletion is defined by patient 5, and distally it is defined by patients 3 and 4. The previously published data on the minimal region of 11q deletion for CLL and mantle cell lymphoma are indicated in the same manner, and the disease type (CLL, chronic lymphocytic leukemia; MCL, mantle cell lymphoma) is indicated in the gap representing the deleted region. The hatched box represents an area that was not analyzed.