Blood volume determination and visualization using^99mTc-labeled red blood cells.

(A) Adult tg mice had a 75% increase of blood volume (wt: n = 4; tg: n = 5), *P < .05. (B) Planar scintiscan showing an increased radioactivity of the tg mouse in the areas of the heart, lung, liver, and left abdomen, where the more than 4-fold (data not shown) enlarged spleen was situated.