Cardiovascular data.

(A) Mean arterial pressure measured in the carotid artery was not significantly different between wt and tg mice (wt: n = 12; tg: n = 8). (B) Central venous pressure measured in the cranial vena cava was significantly increased in tg mice (wt: n = 3; tg: n = 5, *P < .05). (C) Cardiac output determined by echocardiography was similar in wt and tg mice (wt: 14.4 ± 4.0 mL/min; tg: 14.8 ± 3.1 mL/min).