Fig. 1.
![Fig. 1. BMP-4 inhibits DNA synthesis in IL-6–dependent myeloma cell lines. / Cell lines were stimulated with 0.1 ng/mL IL-6 (IH-1 and OH-2) or 1 ng/mL IL-6 (ANBL-6), with or without BMP-4, in concentrations as indicated for 72 hours. DNA synthesis was measured by [3H]-thymidine incorporation. Counts were normalized; 100% represents the count obtained with IL-6 alone (absolute counts were 1500 counts per minute (cpm) for IH-1, 2400 cpm for ANBL-6, and 900 cpm for OH-2).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/2/10.1182_blood.v97.2.516/5/h80210582001.jpeg?Expires=1735550679&Signature=FiZaf2v8rnLd5x1kkgOD~BTsqwbkbFe0Z8JBPCBYW6n~cYi9rLgLvFpLAMmjaCSyNyyRcQ7Nyqs2AKWMZq1zLfx9bZDZGM~5lHA6F6-0gW5Mb9XfX3LD5ZSgdjAPVJlteXRNyQgXIcefjYFOVc-qTRlQG9cw~C6VcrW3YVvIUDdnqJ4lmU4vRoI4lLy-pGvtz5SnCZ1ScnTfQDFAkcRPW~qmul2ZUTg0p0T7RFJINGcaIQOmyjf9RYkxPgEx2XCg1zrxaU9PB~kTa-RaDUCemD4K6nQkmsLJ2pm-Rw5pc61nJqdewZ1r-DZKKRge71mgt51nuzs5H6X9IkaVJCTy0A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
BMP-4 inhibits DNA synthesis in IL-6–dependent myeloma cell lines.
Cell lines were stimulated with 0.1 ng/mL IL-6 (IH-1 and OH-2) or 1 ng/mL IL-6 (ANBL-6), with or without BMP-4, in concentrations as indicated for 72 hours. DNA synthesis was measured by [3H]-thymidine incorporation. Counts were normalized; 100% represents the count obtained with IL-6 alone (absolute counts were 1500 counts per minute (cpm) for IH-1, 2400 cpm for ANBL-6, and 900 cpm for OH-2).
