Fig. 8.
BMP-4 inhibits IL-6–induced Stat3 phosphorylation in primary myeloma cells.
Cells from patient 11 were incubated for 4 hours with cytokines, as indicated. Cellular lysates were analyzed by Western blot. Lower panels show total Stat3 protein, and upper panels show specific tyrosine phosphorylation of Stat3 amino acid residue 705.