Impact of IFN-α on the binding of Stat factors to the SIE.

Nonmalignant CD4⁺ T cells (lanes 1 and 2) from patient R respond with the induction of DNA binding molecules to IFN stimulation (lane 2). The dominant Vβ CD4⁺ T-cell population from patient R (lanes 3 and 4) fails to induce DNA binding molecules on stimulation (lane 4). No IFN treatment (lanes 1 and 3); treatment with 500 U IFN-α for 30 minutes (lanes 2 and 4).