Effect of rhIL-11 injections on vWf and FVIII mRNA in wild type mice.

Wild type mice were injected daily for 4 days with placebo (■) or 250 μg/kg rhIL-11 (▨). Organs were then collected, and mRNA was prepared. The quantity of message for (A) vWf or (B) FVIII was measured for 125 ng total RNA by the Taqman method. Levels were normalized to murine GAPDH mRNA levels. No significant differences were found between placebo or rhIL-11–injected animals (n = 5).