Effect of rhIL-11 injections on skin bleeding time in vWf-deficient mice.

vWf^−/− mice were injected daily with placebo (○) or 250 μg/kg rhIL-11 (●) for 7 days. An incision (5-mm long by 1-mm deep) was made on the hind leg with an automatic device, and filter paper was applied to the wound for 5 seconds every 15 seconds until cessation of bleeding. The rhIL-11 treatment significantly reduced the skin bleeding time of the vWf^−/− mice (P = .005; n = 6-7).