Selected parameters relevant to hemostasis and thrombogenesis in the mouse strains used for this study. (A) Plasma concentration of VWF^h28 (M1HA and H1HA) compared with endogenous mouse VWF (M1MA and H1MA) measured by enzyme-linked immunosorbent assay (ELISA) using anti-human VWF polyclonal antibodies. M1MA, n = 23; M1HA, n = 13; H1MA, n = 13; H1HA, n = 15. (B) Multimer analysis of mouse plasma samples showing the presence of full-range multimers in all 4 tested mouse strains. (C) Platelet counts. (D) FVIII activity of mouse plasma serially diluted with human FVIII-deficient plasma and measured in a thrombin generation test initiated by 0.15 pM tissue factor/200 pM FIXa, and CaCl₂. Values are percent of normal human reference plasma. All numerical data are shown with mean ± 95% confidence intervals. Statistical analysis performed with one-way analysis of variance (ANOVA) with Tukey’s multiple comparison test (P = .001405) and Kruskal-Wallis nonparametric test followed by Dunn’s multiple comparison test (P = .002574). **P < .01 where indicated; all other comparisons were not significantly different.