Figure 4.
Accelerated, but not conventional, LTI markedly increases the percentages of 7AADint/hiCRThi, 7AADint/hiHsp70hi, and 7AADint/hiHsp90hicells in A20 and BL3750 B-cell lymphomas. (A) Representative 2-color FACS patterns of the percentages of 7AADint/hiCRThi, 7AADint/hiHsp70hi, and 7AADint/hiHsp90hi cells on CD19+ gated BALB/c A20 lymphoma cells within the boxes from 3 groups of mice. (B) Percentages (mean ± standard error of the mean) of 7AADint/hiCRThi (top panel), 7AADint/hiHsp70hi (middle panel), and 7AADint/hiHsp90hi (bottom panel) cells in panel A. n = 5 mice per group. (C) Representative 2-color FACS patterns of the percentages of 7AADint/hiCRThi, 7AADint/hiHsp70hi, and 7AADint/hiHsp90hi cells on CD19+ gated BL3750 lymphoma cells contained in boxes from 4 groups of mice. (D) Percentages (mean ± standard error of the mean) of 7AADint/hiCRThi, 7AADint/hiHsp70hi, and 7AADint/hiHsp90hi cells in panel C. n = 4 mice per group. Only significant P values are shown. *P < .05, **P < .01, Mann-Whitney U test.