Chronic low-dose LPS stimulation of Vav-KDM6B mice led to a MDS-like hematopoietic phenotype. Results are based on adult Vav-KDM6B mice and WT controls treated with low-dose LPS (6 µg/mouse) or PBS every other day for 6 weeks (LPS: N = 13 Vav-KDM6B, N = 13 WT; PBS: N = 17 Vav-KDM6B, N = 17 WT, unless otherwise noted). All error bars are based on ± SEM. (A-B) Complete blood count results for WBCs and neutrophils. (C) Example images of hematoxylin and eosin-stained BM sections of indicated mice. Scale bars represent 1 mm. (D) Whole BM (WBM) cell counts. (E-F) Percentages of myeloid (Gr1-positive) and lymphoid (B220-positive) cells in the BM of indicated mice. (G-H) Example images and counts of BM cytospin showing megakaryocytic dysplasia in LPS-treated KDM6B mice (LPS: N = 4 Vav-KDM6B, N = 4 WT; PBS: N = 5 Vav-KDM6B, N = 5 WT). Scale bars represent 15 μm.