Multivariate analysis of factors influencing subclone formation. Multivariate analysis of factors influencing subclone formation in a forest plot, both for PC-AL and PC–non-AL separately as well as combined. In both the PC-AL group and PC–non-AL control group, t(11;14) as main clone aberration was associated with decreased subclone formation, whereas hyperdiploidy was associated with increased subclone formation in the PC–non-AL control group. The effects were similar in the PC-AL and non–PC-AL groups, suggesting that subclone formation is an inherent trait of the respective cytogenetic aberrations, irrespective of clinical disease.