Platelet caspase-1 activity is upregulated in SCD patients in steady state and further increased during an acute pain crisis. Platelet caspase-1 activity is upregulated in SCD patients in steady state (SS) compared with healthy controls (A) and is further elevated when measured in the same SCD patients experiencing an acute pain crisis (paired samples) (B). Data are shown as median with IQR and minimum and maximum values (A) and before-after plot (B). The P values were calculated using the Mann-Whitney U test (A) and the Wilcoxon-signed rank test (B).