Peripheral α-granules appear to decondense first upon stimulation. Renderings from SBF-SEM of 5 different platelets, stimulated for 90 seconds (A-E) are shown. Condensed granules are rendered in blue, decondensed granules are rendered in tan/yellow, and PM is rendered in green. Arrows point to examples of peripherally located, decondensed granules. Quantification of granule sizes is tabulated in Table 1. Bar represents 1 μm.