Graphic summary of the role of α-granule decondensation in granule cargo release. In this illustration, we represent the observed steps that occur during decondensation and release of α-granule contents. The v- and t-SNAREs (ie, VAMP8/7 and syntaxin-11/SNAP23) are indicated. SNARE-mediated fusion, water influx (blue circles), and granule/matrix decondensation are depicted as a sequence of events. Both primary and compound granule-granule fusion are shown.