CCND3 mutations in MLL-rearranged AML and disease subtype–specific pattern of CCND1, CCND2, and CCND3 mutations and expression. (A) Domain structure and location of CCND3 mutations in pediatric and adult MLL-rearranged AML. Lollipop plots were generated using ProteinPaint (https://pecan.stjude.org/proteinpaint/). (B) Mutations of CCND1, CCND2, and CCND3 in pediatric AML patients with t(8;21) and MLL rearrangements (MLL-r). (C) Messenger RNA expression levels of CCND1, CCND2, and CCND3 in t(8;21) AML (n = 60) and MLL-rearranged AML (n = 43). ***P < .001.