Figure 5.
![Figure 5. Proliferation of WT, miR-146a KO, and miR-146b KO B cells in response to LPS, anti-CD40, and anti-IgM antibody. Splenic B cells (CD19+) were incubated for 48 hours in the presence of media only (none) or the indicated mitogens (0.1, 1, or 10 μg/mL LPS; 0.1, 1, or 5 μg/mL anti-CD40; and 10 μg/mL anti-IgM). Proliferation was measured by [3H]-thymidine incorporation. Data are presented as mean ± SEM. n = 6. *P < .05, **P < .01. cpm, counts per minute.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/2/23/10.1182_bloodadvances.2018017954/8/advances017954f5.png?Expires=1735536788&Signature=GmPvwu6Zr50yuqL5mSY9HN1eC61aeDq1-PeVzxJVfgBTs3Y12dqOnYBsh93PMvE5EKMLRgTMMUfeJigZQ8EBpIunXJo36yPmv8-rBhc~0xdXiHLje5b3r2uWCG29-wXyI-qUKiwjQ37NXbhY09we6wNeRSZ7RCAel2a9d68tyUEzN8VnvZgls5bX5lRN~kpJYmfMx-2C1oWM0uLZnuiI1nPpmvAbnmXgkKtpZymWjDA6BbWs0duDFE5usnoCkKl70iX7BZlr9bgn7HgWuGfMVfQ0H4MKIv8ZvarSX8vySB1P8uFlAbp1bqeK65rugHQWGwvnJ3OwAModxu~Q3rnIXg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Proliferation of WT, miR-146a KO, and miR-146b KO B cells in response to LPS, anti-CD40, and anti-IgM antibody. Splenic B cells (CD19+) were incubated for 48 hours in the presence of media only (none) or the indicated mitogens (0.1, 1, or 10 μg/mL LPS; 0.1, 1, or 5 μg/mL anti-CD40; and 10 μg/mL anti-IgM). Proliferation was measured by [3H]-thymidine incorporation. Data are presented as mean ± SEM. n = 6. *P < .05, **P < .01. cpm, counts per minute.