CNVs at CREs are associated with CD69 expression in DLBCL. (A) Loss of a CRE interacting with the CD69 promoter. The top panel shows the position of CNVs at CRE, all of which are copy number losses. The second panel shows chromatin looping interactions between the CD69 promoter and CREs, with the interaction between the promoter and the CNV-disrupted CRE colored yellow. The third panel details chromatin immunoprecipitation–sequencing histone mark signals in naive B cells. The bottom panel shows the positions of BRD4-bound enhancers in DLBCL.³⁵  (B) CNV status at CRE and CD69 expression in DLBCL tumors. (C) CNV status at CRE and ETV6 expression in DLBCL tumors. Association between copy number status and gene expression assessed through linear regression. Boxplot hinges extend to the most extreme data points that are no more than 1.5 times the interquartile range from the box.