CNVs at CREs are associated with IGLL5 expression in B-cell malignancies. (A) The loss of a CRE interacting with the IGLL5 promoter. The top panel shows the position of CNVs at the CRE, all of which are losses, and the position of the VJ junction. The second panel shows chromatin looping interactions between the IGLL5 promoter and CREs, with the interaction between the promoter and the considered CRE colored yellow. The third panel details chromatin immunoprecipitation–sequencing histone mark signals in naive B cells. The bottom panel shows the positions of BRD4-bound enhancers in DLBCL.³⁵  CNV status at CRE and gene expression in DLBCL (B) and FL (C) tumors. (D) CNV status at CRE and gene expression in secondary analysis of CLL tumors. Association between copy number status and gene expression assessed through linear regression. Boxplot hinges extend to the most extreme data points that are no more than 1.5 times the interquartile range from the box.