TAK-243 induces DNA damage and cell cycle arrest in DLBCL cells. OCI-LY19 (A) and OCI-LY3 (B) cells were treated with TAK-243, and proteins were lysed at the indicated time points and subjected to immunoblotting. (C-D) OCI-LY19 cells were treated with TAK-243 for 24 hours. Flow cytometry was used to measure DNA content in cells stained with propidium iodide. DMSO, dimethyl sulfoxide.