Outcome of 3239 patients in the iBFM cohort stratified by the original genetic risk group. (A-B) Kaplan-Meier survival curves (A) and forest plot (B) depicting the hazard ratio and 95% confidence interval from univariate Cox regression models comparing the EFS for GEN-PR vs GEN-GR. Patients in the Israeli National Study were excluded from the forest plot, as no event occurred in the GEN-GR group.