Figure 4.
Adjusted odds ratios of infection subtypes for each incremental 10-mg/dL increase in mean glucose. Odds ratios for SBI, viremia/viruria, and fungal infection are adjusted for age group, HSCT type, pretransplant radiation, GVHD, and post-HSCT steroids. After adjusting for age group, pre-HSCT radiation, HSCT type, severe (grade 2, grade 4, or chronic) GVHD diagnosis, and post-HSCT steroids, the risk of SBI and fungal infection increased with increased mean glucose at all time intervals, and the risk of viremia/viruria increased with increased pre-HSCT and days 0 to 100 mean glucose. For example, with each 10-mg/dL increase in pretransplant glucose, there was a 29.8% (95% CI, 12.4-49.9) increase in SBI (P < .0001), a 26.0% (95% CI, 6.8-48.8) increase in viremia/viruria (P = .006), and a 27.0% (95% CI, 3.1-56.3) increase in fungal infection (P = .02). Similar relationships were noted for the days 0 to 100 interval. After adjusting for the aforementioned variables, there was an increased risk for GVHD (grade 3 or 4 or chronic) with increasing days 0 to 100 mean glucose.