ELMO1 deficiency is dispensable for CLEC-2–mediated platelet reactivity. Washed platelets isolated from WT, ELMO1^−/−, and RhoG^−/− mice were diluted to 1.5 × 10⁸ and stimulated with either 5 nM (A) or 10 nM (C) rhodocytin, and subsequent aggregations and secretions were recorded. (B,D) Quantification of ATP secretion expressed as mean ± standard error of the mean following platelet stimulation with either 5 nM or 10 nM rhodocytin.