HMGA2-overexpressing HSPCs show gene-expression signatures associated with myeloerythroid differentiation. (A-B) GSEA to identify gene sets enriched or depleted in HMGA2-overexpressing CD34⁺ cells compared with controls. GSEA plots were generated using population-specific gene signatures described in previous studies for human hematopoietic cells. (C) Top 20 upregulated genes in HMGA2-overexpressing cells. CMP, common myeloid progenitor; EryUP, erythroid upregulated; FDR, false discovery rate; NES, normalized enrichment score.