Nucleosomes have other origins besides neutrophils. (A) Nucleosomes and EA complex levels in plasma of humans injected with LPS at t = 0 (n = 8). (B) Nucleosome levels positively correlate to EA complex levels in LPS-challenged subjects. (C) Nucleosome levels in septic patients with neutrophil activation on admission (>100 ng/mL, n = 8) or without neutrophil activation (<100 ng/mL, n = 12) are not statistically different. (D) Nucleosomes and EA complex levels in plasma of sepsis patients (n = 20) at start of admission and during admission to the hospital. (E) No correlation exists between nucleosome and EA complex levels in the previously mentioned sepsis patients. Data are represented as mean ± standard error (A,D) or median ± interquartile range (C). P < .05 was considered significant. ns, not significant.