Changes in miR-155 expression in GCB-DLBCL cell lines affect vincristine response. (A) Schematic overview of lentiviral vector plasmids used as control (i), for expression of miR-155 (ii) and TuD-155 (iii) inhibitor in fusion with eGFP. (B-E) Up- and downregulation of miR-155 was detected by RT-qPCR in (Bi,Ci) SU-DHL-5 and (Di,Ei) OCI-Ly7 cells and followed by vincristine dose-response analysis. (Bii,Cii,Dii,Eii) Drug response is illustrated as percentage of living cells related to the no-drug treated condition. CMV, cytomegalovirus promoter; LTR, long terminal repeat; NQ, normalized quantity; PGK, phosphoglycerate kinase promoter; WPRE, woodchuck hepatitis virus posttranscriptional regulatory element.