Inhibitors of VWF self-association. (A-B) Studies similar to Figure 5B-C were performed, by shearing 1:50 diluted PRP with 2.5 µg/mL ΔA1-647 and 5 µg/mL WT-VWF. HEPES buffer was replaced by VWF-deficient plasma in one case. In other cases, 500µg/mL ApoA-I or HDL was added. Studies were performed in the absence (A) and presence (B) of exogenous calcium. VWF self-association was reduced by lipoproteins in panel A. *P < .05 with respect to other treatments at indicated times.