Impact of low-dose IL-2 on thymic production of CD4Tregs and CD4Tcons. Percentage of RTEs is shown on the left and absolute cell numbers (cells per microliter) in the peripheral blood at each time point are shown on the right. Box plots on the left depict the 75th percentile, median, and 25th percentile values; whiskers represent maximum and minimum values. Dots depict individual HDs or patients. Graphs on the right show median cell counts per microliter for each population and the corresponding median in HDs, with the interquartile range (whisker bars). Time points represent weeks (W) and months (M) after IL-2 initiation. Number of patients evaluated at each time point is indicated at the bottom of the image. (A) RTE CD4Tregs in patients (blue) and HDs (gray). *P < .05, absolute cell counts compared with baseline (baseline), 2-sided Wilcoxon signed-rank test. (B) RTE CD4Tcons in patients (orange) and HD (gray).