Clinically relevant CMML phenotypes in the patient-derived NUP98-HBO1 BMT mice. (A) White blood cell (WBC) counts, hemoglobin (Hb), mean corpuscular volume (MCV), and platelet (Plts) counts in PB from the control mice transplanted with empty vector transduced cell (Control) and NUP98-HBO1 BMT mice (NUP98-HBO1) at 8 to 10 weeks after transplantation (n = 5 per group). Data are presented as mean ± standard deviation (SD). (B) Diff-Quick (Modified Giemsa) staining of PB smear from the NUP98-HBO1 BMT mice. Scale bar, 20 µm. (C-D) Representative images (C; scale bar, 10 mm) and weight (D) of the spleen from the control and NUP98-HBO1 BMT mice. Data are presented as mean ± SD. (E) Spleen sections from the control and NUP98-HBO1 BMT mice. Scale bar, 200 µm (original magnification ×40; hematoxylin and eosin stain). (F) BM cellularity in the indicated mice. (G) BM sections from the control and NUP98-HBO1 BMT mice. Scale bar, 40 µm (original magnification ×200; hematoxylin and eosin stain). (H) BM cells from the control and NUP98-HBO1 BMT mice. Scale bar, 20 µm (original magnification ×1000; Diff-Quick stain). **P < .01, ***P < .001, ****P < .0001.