CD47 expression on Sézary cells is under influence of Th2 cytokines. (A) Cytokine concentration in peripheral blood of Sézary patients (n = 11) vs age-matched healthy volunteers (n = 15). Mean ± SD is depicted. Two-tailed unpaired Student t test (*P < .05; **P < .01). (B) Percentage of CD47 on the surface of Sézary cells (CD4⁺Vβ⁺, red) vs nonmalignant T cells from the same patients (CD4⁺Vβ⁻, blue) in relationship to nonstimulated cells following 48-hour incubation with IL-2 (200 IU/mL), IL-4 (20 ng/mL), IL-6 (20 ng/mL), IL-7 (20 ng/mL), IL-10 (20 ng/mL), IL-12 (50 ng/mL), IL-13 (20 ng/mL), IL-17 (20 ng/mL), IL-23 (20 ng/mL), IFN-γ (20 ng/mL), or TNF-α (20 ng/mL). Mean ± SD is depicted. Two-tailed unpaired Student t test (*P < .05). ns, not significant.