VWF peptides identified in a MAPPs assay and effect of co-incubation with different FVIII products. (A) For each donor, number of VWF peptides identified in the MAPPs assay is shown by the bars; pdVWF was coincubated with either FL-rFVIII (red) or pdFVIII (blue). Left panel, The MHC-II-DRB1 alleles for each donor and their respective frequencies in African, Asian, and white populations. (B) Location of the VWF peptides identified in the MAPPs assay shown on the VWF primary sequence (x-axis). At each location, the subjects are identified by the color codes.